Hydrochloric Acid → HCID 42606392, compound

HRID 885467Notes

Reaction equation

HRID 885467 reaction equation
[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4][CH2:5][C:6]1([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)[C:14]2[C:9](=[CH:10][C:11]([C:15]#[N:16])=[CH:12][CH:13]=2)[CH2:8][O:7]1.[ClH:26]>ClCCl.C(OCC)C>[ClH:26].[CH3:25][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]1([C:17]2[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=2)[C:14]2[C:9](=[CH:10][C:11]([C:15]#[N:16])=[CH:12][CH:13]=2)[CH2:8][O:7]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 426063901148027-74-0

Product 1

HCID 42606392HCID 42606392, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

8.3 g (24.7 mmol) of the 1-{3-(dimethylamino)propyl}-1-(4-methoxyphenyl)-1,3-dihydro-5-isobenzofurancarbonitrile prepared in Example 1 was dissolved in 50 ml of dichloromethane, and 24.7 ml (494 mmol) of 2 M hydrochloric acid in diethyl ether was added dropwise at room temperature. The mixture was then stirred for 0.5 hr. After the solution was discarded, the precipitate was washed with diethylether and dried to afford 8.7 g of the pale yellow target compound (yield: 95%).

Workup

  1. washthe precipitate was washed with diethylether
  2. customdried

Sources & evidence

ORD record
ord-5c4b18a26b0241f9a6643a09fdfc53f4
Source dataset
uspto-grants-2012_08
Patent number
US08242159B2

Reaction notes

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