2,2-Difluoro-2-phenylethanol → α,α-Difluorobenzeneacetaldehyde

HRID 885533Notes

Reaction equation

HRID 885533 reaction equation
[F:1][C:2]([F:11])([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][OH:4].C1(CCCCOCCC=O)C=CC=CC=1>>[F:1][C:2]([F:11])([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[CH:3]=[O:4]

Participants

3

Reactant 2

HCID 97938912,2-Difluoro-2-phenylethanolHCID 866583073-(4-Phenylbutoxy)propionaldehyde

Product 1

HCID 14644933α,α-Difluorobenzeneacetaldehyde

Procedure

Obtained from Intermediate 6 (1.0 g, 6.3 mmol) by the procedure described for the Intermediate 13. The title compound was obtained (0.88 g, 86%) as oil.

Sources & evidence

ORD record
ord-541a4cc110524f05b479b3d3bf17c768
Source dataset
uspto-grants-2012_08
Patent number
US08242177B2

Reaction notes

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