3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol → 3-(2,2-Difluoro-2-phenylethoxy)propanal

HRID 885559Notes

Reaction equation

HRID 885559 reaction equation
[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][OH:8].C1(CCCCOCCC=O)C=CC=CC=1>>[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]=[O:8]

Participants

3

Reactant 2

HCID 672459503-(2,2-Difluoro-2-phenylethoxy)propan-1-olHCID 866583073-(4-Phenylbutoxy)propionaldehyde

Product 1

HCID 866583133-(2,2-Difluoro-2-phenylethoxy)propanalYield 60.3%

Procedure

Obtained from Intermediate 81 (3.0 g, 14.4 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with methylene chloride gave the title compound (1.86 g, 60%) as oil.

Workup

  1. customPurification by column chromatography with silica gel eluting with methylene chloride

Sources & evidence

ORD record
ord-f24f58ed7c6c49a7b7990d40c8be8014
Source dataset
uspto-grants-2012_08
Patent number
US08242177B2

Reaction notes

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