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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885559Generated: October 31, 2026

3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol → 3-(2,2-Difluoro-2-phenylethoxy)propanal

https://huagongshe.com/reaction/885559

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,2-Difluoro-2-phenylethoxy)propan-1-olHCID 67245950—
Reactant3-(4-Phenylbutoxy)propionaldehydeHCID 86658307—
Product3-(2,2-Difluoro-2-phenylethoxy)propanalHCID 8665831360.3%

Reaction Steps

Obtained from Intermediate 81 (3.0 g, 14.4 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with methylene chloride gave the title compound (1.86 g, 60%) as oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08242177B2
Source datasetuspto-grants-2012_08
ORD IDord-f24f58ed7c6c49a7b7990d40c8be8014
Source noteuspto-grants-2012_08