HCID 67246711, compound → HCID 86658314, compound

HRID 885562Notes

Reaction equation

HRID 885562 reaction equation
[F:1][C:2]([F:20])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:3][O:4][CH2:5][CH2:6][C:7]([F:13])([F:12])[CH2:8][CH2:9][CH:10]=C.FC(F)(CCOCCCCC1C=CC=CC=1)CCC=[O:26]>>[F:1][C:2]([F:20])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:3][O:4][CH2:5][CH2:6][C:7]([F:13])([F:12])[CH2:8][CH2:9][CH:10]=[O:26]

Participants

3

Reactant 2

HCID 67246711HCID 67246711, compoundHCID 86658308HCID 86658308, compound

Product 1

HCID 86658314HCID 86658314, compoundYield 60%

Procedure

Obtained from Intermediate 85 (0.80 g, 2.7 mmol) by the procedure described in Intermediate 17. Purification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (1:5) gave the title compound (0.48 g, 60%) as oil.

Workup

  1. customPurification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (1:5)

Sources & evidence

ORD record
ord-e1bc41d51d4f4a29b21357ed487a9842
Source dataset
uspto-grants-2012_08
Patent number
US08242177B2

Reaction notes

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