Trifluoroacetic acid → (E)-3-(4-{(E)-3-[4-(1-methyl-piperidin-4-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoro acetate

HRID 885835노트

반응식

HRID 885835 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C([O:12][C:13](=[O:39])/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][C:19](/[CH:22]=[CH:23]/[C:24]([C:26]2[CH:31]=[CH:30][C:29]([CH:32]3[CH2:37][CH2:36][N:35]([CH3:38])[CH2:34][CH2:33]3)=[CH:28][CH:27]=2)=[O:25])=[CH:18][CH:17]=1)(C)(C)C>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:38][N:35]1[CH2:34][CH2:33][CH:32]([C:29]2[CH:28]=[CH:27][C:26]([C:24](=[O:25])/[CH:23]=[CH:22]/[C:19]3[CH:18]=[CH:17][C:16](/[CH:15]=[CH:14]/[C:13]([OH:39])=[O:12])=[CH:21][CH:20]=3)=[CH:31][CH:30]=2)[CH2:37][CH2:36]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67049486(E)-3-(4-{(E)-3-[4-(1-methyl-piperidin-4-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid tert-butyl ester

생성물 1

HCID 67049577(E)-3-(4-{(E)-3-[4-(1-methyl-piperidin-4-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoro acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2 ml of trifluoroacetic acid were added to a solution of (E)-3-(4-{(E)-3-[4-(1-methyl-piperidin-4-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid tert-butyl ester (270 mg, 0.63 mmol) in 10 ml of DCM. The solution was stirred at room temperature for 2 hours. The solvent was then removed until dryness and 300 mg of (E)-3-(4-{(E)-3-[4-(1-methyl-piperidin-4-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoro acetate were obtained as a yellow solid.

후처리

  1. customThe solvent was then removed until dryness

출처 및 근거

ORD 기록
ord-2345eedf898b4d9a91700051555309b6
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242175B2

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