Potassium Hydroxide → HCID 67049858, compound

HRID 885850Notes

Reaction equation

HRID 885850 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:9](=[O:11])[CH3:10])[CH:6]=[CH:7][CH:8]=1.[CH:12]([C:14]1[CH:24]=[CH:23][C:17]([CH:18]=[CH:19][C:20]([OH:22])=[O:21])=[CH:16][CH:15]=1)=O.[OH-].[K+]>CCO>[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:9](=[O:11])/[CH:10]=[CH:12]/[C:14]2[CH:15]=[CH:16][C:17](/[CH:18]=[CH:19]/[C:20]([OH:22])=[O:21])=[CH:23][CH:24]=2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 980772-Propenoic acid, 3-(4-formylphenyl)-HCID 149952181-[3-(Hydroxymethyl)phenyl]ethan-1-one

Product 1

HCID 67049858HCID 67049858, compoundYield 75.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(3-hydroxymethyl-phenyl)-ethanone (810 mg), 4-formylcinnamic acid (950 mg, 5.4 mmol) and 1.7 M KOH (6.4 ml) in EtOH (40 ml) was stirred at room temperature for 18 h. The resulting precipitate was filtered and washed with EtOH to give 1.25 g of (E)-3-{4-[(E)-3-(3-hydroxymethyl-phenyl)-3-oxo-propenyl]-phenyl}-acrylic acid as its potassium salt.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with EtOH

Sources & evidence

ORD record
ord-c34bc2a467df47f9a1ce65996bb2b68f
Source dataset
uspto-grants-2012_08
Patent number
US08242175B2

Reaction notes

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