HRID885938

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81668

1-(2-Chloroethyl)pyrrolidine hydrochloride

C6H13Cl2N

2 次

HCID2774010

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C9H15BN2O2

PRODUCTS

生成物

HCID58885861

1-[2-(Pyrrolidin-1-yl)ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C15H26BN3O2

CONDITIONS

反应条件

温度: 90 °C

PROCEDURE

实验过程

The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 1-(2-chloroethyl)pyrrolidine hydrochloride according to Method AC (heating to 90° C. for 6 days before addition of further 1-(2-chloroethyl)pyrrolidine hydrochloride, and heating to 90° C. for a further 3 days) and was isolated as a brown gum (45%). LCMS (ES+) 292 (M+H)+, RT 1.81 minutes (Method 1).