HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885938Generated: November 1, 2026
1-(2-Chloroethyl)pyrrolidine hydrochloride → 1-(2-(pyrrolidin-1-yl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
https://huagongshe.com/reaction/885938
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(2-Chloroethyl)pyrrolidine hydrochloride | HCID 81668 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2774010 | — |
| Product | 1-(2-(pyrrolidin-1-yl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 58885861 | — |
Reaction Steps
The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 1-(2-chloroethyl)pyrrolidine hydrochloride according to Method AC (heating to 90° C. for 6 days before addition of further 1-(2-chloroethyl)pyrrolidine hydrochloride, and heating to 90° C. for a further 3 days) and was isolated as a brown gum (45%). LCMS (ES+) 292 (M+H)+, RT 1.81 minutes (Method 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08242116B2 |
|---|
| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-0ae0a80ff3494422a8949cd746358b05 |
|---|
| Source note | uspto-grants-2012_08 |
|---|
