HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885940Generated: October 30, 2026
4-Methylmorpholine → 3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine
https://huagongshe.com/reaction/885940
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 3-(Chloromethyl)pyridine | HCID 18358 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2774010 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine | HCID 17999185 | — |
Reaction Steps
The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 3-picolyl chloride (prepared from the hydrochloride salt using a pre-swelled suspension of morpholinomethyl polystyrene in DMF) according to Method AC (heating to 100° C. under microwave irradiation for 2 h) and was isolated as a brown oil (71%). LCMS (ES+) 286 (M+H)+, RT 1.98 minutes (Method 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08242116B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-72f2807011534528a47a610da987e871 |
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| Source note | uspto-grants-2012_08 |
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