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HRID885940

反应详情

EQUATION

反应方程式

HRID 885940 的结构方程式

REACTANTS

反应物

3
反应SMILES：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

反应SMILES：ClCc1cccnc1
HCID18358

3-(Chloromethyl)pyridine

C6H6ClN

反应SMILES：CC1(C)OB(c2cn[nH]c2)OC1(C)C
HCID2774010

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C9H15BN2O2

PRODUCTS

产物

1
反应SMILES：CC1(C)OB(c2cnn(Cc3cccnc3)c2)OC1(C)C
HCID17999185

3-{[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}pyridine

C15H20BN3O2

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CN(C)C=O
溶剂HCID6228

Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 3-picolyl chloride (prepared from the hydrochloride salt using a pre-swelled suspension of morpholinomethyl polystyrene in DMF) according to Method AC (heating to 100° C. under microwave irradiation for 2 h) and was isolated as a brown oil (71%). LCMS (ES+) 286 (M+H)+, RT 1.98 minutes (Method 1).