huagongshe.com
HRID885941

反应详情

EQUATION

反应方程式

HRID 885941 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2cn[nH]c2)OC1(C)C
HCID2774010

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C9H15BN2O2

结构：CN1CCCCC1CCCl.Cl
HCID12432704

2-(2-Chloroethyl)-1-methylpiperidine--hydrogen chloride (1/1)

C8H17Cl2N

2 次

PRODUCTS

生成物

1
结构：CN1CCCCC1CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1
HCID58354598

1-Methyl-2-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl]piperidine

C17H30BN3O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

CONDITIONS

反应条件

温度
90 °C

PROCEDURE

实验过程

The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 2-(2-chloroethyl)-1-methylpiperidine hydrochloride according to Method AC (heating to 90° C. for 6 days before addition of further 2-(2-chloroethyl)-1-methylpiperidine hydrochloride and triethylamine, then heating to 90° C. for a further 3 days) and was isolated as a brown oil (quantitative). LCMS (ES+) 320 (M+H)+, RT 1.85 minutes (Method 1).

WORKUP

后处理

  1. customwas isolated as a brown oil (quantitative)
  2. customLCMS (ES+) 320 (M+H)+, RT 1.85 minutes (Method 1)