反应详情

To a solution of (3-Bromo-phenyl)-oxo-acetic acid ethyl ester (1 g, 3.9 mmol) in methanol (10 mL) was added potassium hydroxide (2 mL, 50% w/v in water) and the resulting mixture was stirred at room temperature for 30 minutes. Hydrochloric acid (1 N) was added to adjust to pH 4. The mixture was extracted with ethyl acetate (5 mL×4) and the combined organic extracts were dried over sodium sulfate, filtered, and concentrated. The residue was used in next step without further purification (0.8 g, 89% yield). MS: m/z 230 (M−H+).

1. extractionThe mixture was extracted with ethyl acetate (5 mL×4)
2. dry with materialthe combined organic extracts were dried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was used in next step without further purification (0.8 g, 89% yield)