反应详情

2400 g Rotigotine hydrochloride were added to a solution of 272.8 g NaOH in 3488 g ethanol (96%). The resulting mixture was stirred for approximately 10 minutes. Then 379.2 g of sodium phosphate buffer solution (27.6 g Na2HPO4×2H2O) and 53.2 g Na2HPO4×2H2O in 298.5 g water) was added. Insoluble or precipitated solids were separated from the mixture by filtration. The filter was rinsed with 964 g ethanol (96%) to obtain a particle-free ethanolic solution of rotigotine essentially in the form of the free base.

1. customInsoluble or precipitated solids
2. customwere separated from the mixture by filtration
3. washThe filter was rinsed with 964 g ethanol (96%)