Water → HCID 57865098, compound

HRID 886664Notes

Reaction equation

HRID 886664 reaction equation
N1N[N:3]=[N:4][C:5]=1[C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2.[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[C:22](Cl)(=[O:32])[C:23]1[CH:31]=[CH:30][CH:29]=[C:25]([C:26](Cl)=[O:27])[CH:24]=1.O>CCCCCC.C(Cl)(Cl)Cl>[N:16]1[C:21]2[C:20](=[CH:7][CH:6]=[CH:15][CH:14]=2)[CH:19]=[C:18]([C:5]2[O:32][C:22]([C:23]3[CH:31]=[CH:30][CH:29]=[C:25]([C:26]4[O:27][C:5]([C:6]5[CH:7]=[N:8][C:9]6[C:14]([CH:15]=5)=[CH:13][CH:12]=[CH:11][CH:10]=6)=[N:4][N:3]=4)[CH:24]=3)=[N:3][N:4]=2)[CH:17]=1

Participants

7

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 7451Isophthaloyl chlorideHCID 223956903-(2H-Tetrazol-5-yl)quinoline

Product 1

HCID 57865098HCID 57865098, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8058HexaneSolvent

Conditions

Temperature
100 °C

Procedure

After dissolving 4.0 g of 3-(2H-tetrazole-5-yl)-quinoline into 60 ml of dehydrated pyridine, 2.1 g of isophthaloylchloride was added. The mixture was heated to 100° C. and stirred under reflux for 3 hours. After cooling to a room temperature, the reaction solution was poured into water to collect a precipitated solid by suction filtration, and the solid was washed with water. The solid was dried under vacuum at 70° C. for 20 hours to obtain a grayish white crude product. After dissolving the thus-obtained crude product into chloroform, hexane was added to allow purification by crystallization, thereby obtaining 3.90 g of 3QOXDm (31) (yield: 82%). NMR analysis (see FIG. 4) was performed for identification of the product. The results of the NMR analysis are as follows. 9.70 ppm (2H), 9.02 ppm (1H), 8.98 ppm (2H), 8.46 ppm (2H), 8.24 ppm (2H), 8.05 ppm (2H), 7.89 ppm (2H), 7.83 ppm (1H), 7.71 ppm (2H).

Workup

  1. additionwas added
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling to a room temperature
  4. customto collect a precipitated solid
  5. filtrationby suction filtration
  6. washthe solid was washed with water
  7. customThe solid was dried under vacuum at 70° C. for 20 hours
  8. customto obtain a grayish white crude product
  9. dissolutionAfter dissolving the
  10. additionwas added
  11. custompurification
  12. customby crystallization

Sources & evidence

ORD record
ord-6991daa86be0470caf72a6a45e4099a5
Source dataset
uspto-grants-2012_08
Patent number
US08247087B2

Reaction notes

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