反应详情

A solution of 3,3,3-trifluoro-2-{[(phenylmethyl)amino]methyl}-1,2-propanediol (8.33 g, 33.4 mmol) in ethanol (550 ml) containing palladium hydroxide on carbon (20%, 800 mg) was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered off via a pad of celite and the filtrate was concentrated under reduced pressure, toluene was added and the solution evaporated again under reduced pressure to give the title compound (5.06 g) as an oil.

1. filtrationThe catalyst was filtered off via a pad of celite
2. concentrationthe filtrate was concentrated under reduced pressure, toluene
3. additionwas added
4. customthe solution evaporated again under reduced pressure