2-Chloro-6-fluorobenzoic acid → 5-Amino-N-(2-{[[(2-chloro-6-fluorophenyl)carbonyl](methyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

HRID 886725Notes

Reaction equation

HRID 886725 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:14]([NH:16][CH2:17][C:18]([OH:26])([CH2:23][NH:24][CH3:25])[C:19]([F:22])([F:21])[F:20])=[O:15].[Cl:27][C:28]1[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[C:29]=1[C:30](O)=[O:31]>>[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)[N:5]=[CH:4][C:3]=1[C:14]([NH:16][CH2:17][C:18]([CH2:23][N:24]([C:30]([C:29]1[C:33]([F:37])=[CH:34][CH:35]=[CH:36][C:28]=1[Cl:27])=[O:31])[CH3:25])([OH:26])[C:19]([F:22])([F:21])[F:20])=[O:15]

Participants

3

Reactant 2

HCID 679472-Chloro-6-fluorobenzoic acidHCID 594874925-Amino-1-(4-fluorophenyl)-N-{3,3,3-trifluoro-2-hydroxy-2-[(methylamino)methyl]propyl}-1H-pyrazole-4-carboxamide

Product 1

HCID 594875145-Amino-N-(2-{[[(2-chloro-6-fluorophenyl)carbonyl](methyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

Procedure

Similarly prepared to Example 6 from 5-amino-1-(4-fluorophenyl)-N-{3,3,3-trifluoro-2-hydroxy-2-[(methylamino)methyl]propyl}-1H-pyrazole-4-carboxamide and 2-chloro-6-fluorobenzoic acid.

Sources & evidence

ORD record
ord-845dc400ddb1492ea5533a98e90cd526
Source dataset
uspto-grants-2012_08
Patent number
US08247377B2

Reaction notes

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