HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-fluorobenzoic acid → 5-Amino-N-(2-{[[(2-chloro-6-fluorophenyl)carbonyl](methyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-fluorobenzoic acid | HCID 67947 | — |
| Reactant | 5-Amino-1-(4-fluorophenyl)-N-{3,3,3-trifluoro-2-hydroxy-2-[(methylamino)methyl]propyl}-1H-pyrazole-4-carboxamide | HCID 59487492 | — |
| Product | 5-Amino-N-(2-{[[(2-chloro-6-fluorophenyl)carbonyl](methyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide | HCID 59487514 | — |
Reaction Steps
Similarly prepared to Example 6 from 5-amino-1-(4-fluorophenyl)-N-{3,3,3-trifluoro-2-hydroxy-2-[(methylamino)methyl]propyl}-1H-pyrazole-4-carboxamide and 2-chloro-6-fluorobenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247377B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-845dc400ddb1492ea5533a98e90cd526 |
| Source note | uspto-grants-2012_08 |