反应详情

温度

150 °C

2-Aminothiophene-3-carboxamide (13 g, 92 mmol) and potassium ethylxanthate (48 g, 275 mmol) were mixed together and added to DMF (300 mL). The resulting mixture was heated to 150° C. for 6 hrs, then cooled to RT and concentrated on the rotovap under reduced pressure at 90° C. The residue was diluted with 300 mL of aqueous citric acid (5%) and cooled to 0° C. and stirred for 30 min. The tan powder was filtered and dried overnight to give (11.5 g) of the title compound MS (ES+): 185 (M+H)+.

1. temperaturecooled to RT
2. concentrationconcentrated on the rotovap under reduced pressure at 90° C
3. additionThe residue was diluted with 300 mL of aqueous citric acid (5%)
4. temperaturecooled to 0° C.
5. filtrationThe tan powder was filtered
6. customdried overnight