反应详情

温度

50 °C

To the 4-chloro-6-methyl-2-(methylthio)pyrimidine from above was added 30 mL of a solution of 70% ethylamine in water. The reaction mixture was heated to 50° C. for 3 h. After completion, excess ethylamine was evaporated on rotary evaporator under vacuum. The solid was filtered and dried under vacuum to afford N-ethyl-6-methyl-2-(methylthio)pyrimidin-4-amine (20 g, 90% yield).

1. customAfter completion, excess ethylamine was evaporated on rotary evaporator under vacuum
2. filtrationThe solid was filtered
3. customdried under vacuum