HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 886777Generated: October 31, 2026
Ethylamine → N-Ethyl-6-methyl-2-(methylsulfanyl)pyrimidin-4-amine
https://huagongshe.com/reaction/886777
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 4-Chloro-6-methyl-2-(methylthio)pyrimidine | HCID 241163 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Ethyl-6-methyl-2-(methylsulfanyl)pyrimidin-4-amine | HCID 57606957 | 90% |
Reaction Steps
To the 4-chloro-6-methyl-2-(methylthio)pyrimidine from above was added 30 mL of a solution of 70% ethylamine in water. The reaction mixture was heated to 50° C. for 3 h. After completion, excess ethylamine was evaporated on rotary evaporator under vacuum. The solid was filtered and dried under vacuum to afford N-ethyl-6-methyl-2-(methylthio)pyrimidin-4-amine (20 g, 90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08247408B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-57504d35e3c04fd19a960d8fee9c70e8 |
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| Source note | uspto-grants-2012_08 |
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