反应详情

N,N-Dimethyl acetamide dimethyl acetal (75 g, 0.56 mole) was added to a suspension of thiourea (33.0 g, 0.43 mole) in methylene chloride. The mixture was heated under reflux for 4 h. The solvent was removed and the residue was crystallized from 5% MeOH and diethyl ether affording (1E)-N′-(aminocarbonothioyl)-N,N-dimethylethanimidamide (47.8 g, 76% yield).

1. temperatureThe mixture was heated
2. temperatureunder reflux for 4 h
3. customThe solvent was removed
4. customthe residue was crystallized from 5% MeOH and diethyl ether