反应详情

Isopropylamine (100 mL) was added very slowly to 22.0 g (125.96 mmol) of crude 4-chloro-6-methyl-2-(methylthio)pyrimidine in 70 mL of THF in a 350 mL pressure tube. NOTE: Residual POCl3 caused smoking and bubbling, therefore the addition was done at 0° C. Once acid was quenched, an additional 50 mL of isopropylamine was added and the pressure tube was sealed. The reaction vessel was brought to 60° C. and stirred overnight. The LCMS indicate very little starting material. Solvent was evaporated leaving N-isopropyl-6-methyl-2-(methylthio)pyrimidin-4-amine as a viscous yellow oil. The crude material was taken directly to the next step.

1. customResidual POCl3 caused smoking and bubbling
2. additionthe addition
3. customwas done at 0° C
4. customOnce acid was quenched
5. additionan additional 50 mL of isopropylamine was added
6. customthe pressure tube was sealed
7. customwas brought to 60° C.
8. customSolvent was evaporated