Hydrogen chloride-ethyl acetate → HCID 68578382, compound

HRID 886844Notes

Reaction equation

HRID 886844 reaction equation
[C:1]1([C:7]2[CH:24]=[CH:23][C:10]3[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][O:15][C:9]=3[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OCC)(=O)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[C:1]1([C:7]2[CH:24]=[CH:23][C:10]3[CH2:11][NH:12][CH2:13][CH2:14][O:15][C:9]=3[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578790HCID 68578790, compound

Product 1

HCID 68578382HCID 68578382, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 8-phenyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (180 mg, 0.553 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (5 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (131 mg, 90.3%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-c78dc3fff2e243cfbdcf96bfd20be07e
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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