Ethyl Acetate → HCID 68580357, compound

HRID 886846Notes

Reaction equation

HRID 886846 reaction equation
[C:1]1([C:7]2[C:17]3[O:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OCC)(=O)C.C(OCC)(=O)C.[ClH:37]>>[ClH:37].[C:1]1([C:7]2[C:17]3[O:16][CH2:15][CH2:14][NH:13][CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 21866389Hydrogen chloride-ethyl acetateHCID 68580628HCID 68580628, compound

Product 1

HCID 68580357HCID 68580357, compoundYield 73.9%

Procedure

A solution (5 ml) of tert-butyl 9-phenyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (390 mg, 1.20 mmol) and ethyl acetate (1 ml) in 4N hydrogen chloride-ethyl acetate was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (232 mg, 73.9%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-4edbdeef7970427fbd5c79b0827d229d
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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