Hydrogen chloride-ethyl acetate → HCID 68577932, compound

HRID 886862Notes

Reaction equation

HRID 886862 reaction equation
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[C:5]([C:9]2[C:19]3[O:18][CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][C:13]=3[CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.C(OCC)(=O)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[F:28][C:2]([F:1])([F:27])[C:3]1[CH:4]=[C:5]([C:9]2[C:19]3[O:18][CH2:17][CH2:16][NH:15][CH2:14][C:13]=3[CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68577810HCID 68577810, compound

Product 1

HCID 68577932HCID 68577932, compoundYield 68.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-[3-(trifluoromethyl)phenyl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (210 mg, 0.534 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (121 mg, 68.8%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-1a723e44df724124bbcd99b421ad2e0c
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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