Hydrogen chloride-ethyl acetate → HCID 68578420, compound

HRID 886882Notes

Reaction equation

HRID 886882 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:25]=[CH:24][C:11]3[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][O:16][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.C(OCC)(=O)C.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:25]=[CH:24][C:11]3[CH2:12][NH:13][CH2:14][CH2:15][O:16][C:10]=3[CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578398HCID 68578398, compound

Product 1

HCID 68578420HCID 68578420, compoundYield 167.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 8-(4-chlorophenyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (210 mg, 0.584 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (145 mg, 83.8%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-b07de51028c54fd8bcc82fe04f662fb1
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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