Hydrogen chloride-ethyl acetate → HCID 68578175, compound

HRID 886892Notes

Reaction equation

HRID 886892 reaction equation
[C:1]1([C:7]2[C:12]3[CH2:13][N:14](C(OC(C)(C)C)=O)[CH2:15][CH2:16][O:17][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OCC)(=O)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[C:1]1([C:7]2[C:12]3[CH2:13][NH:14][CH2:15][CH2:16][O:17][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578127HCID 68578127, compound

Product 1

HCID 68578175HCID 68578175, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 6-phenyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (90.0 mg, 0.265 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (68.5 mg, 98.7%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-f32ab94133cc4bab87fee3dc3c5f4a7e
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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