Hydrogen chloride-ethyl acetate → HCID 68578186, compound

HRID 886898Notes

Reaction equation

HRID 886898 reaction equation
[CH3:1][C@H:2]1[O:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:26]=[CH:25][C:12]3[CH2:13][N:14](C(OC(C)(C)C)=O)[CH2:15][CH2:16][O:17][C:11]=3[CH:10]=2)[CH2:3]1.C(OCC)(=O)C.[ClH:33]>C(OCC)(=O)C>[ClH:33].[ClH:33].[CH3:1][C@H:2]1[O:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:26]=[CH:25][C:12]3[CH2:13][NH:14][CH2:15][CH2:16][O:17][C:11]=3[CH:10]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578580HCID 68578580, compound

Product 1

HCID 68578186HCID 68578186, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 8-(cis-2,6-dimethylmorpholin-4-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (300 mg, 0.828 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (6 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (225 mg, 81.2%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-574081ceefd2437aa0c2ecf2b1276d4f
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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