Hydrogen chloride-ethyl acetate → HCID 68578156, compound

HRID 886900Notes

Reaction equation

HRID 886900 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11]2[O:17][CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C:12]=2[CH:25]=1.C(OCC)(=O)C.[ClH:32]>C(OCC)(=O)C>[ClH:32].[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11]2[O:17][CH2:16][CH2:15][NH:14][CH2:13][C:12]=2[CH:25]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578287HCID 68578287, compound

Product 1

HCID 68578156HCID 68578156, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 7-(2-methylphenyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (200 mg, 0.589 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (133 mg, 82.1%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-57dd36c6e42b4b9b98c24c39fe8c8b3e
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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