Hydrogen chloride-ethyl acetate → 9-(2-Methyl-3-furyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

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Reaction Steps

A mixture of tert-butyl 9-(2-methyl-3-furyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (300 mg, 0.911 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (3 ml) was stirred at room temperature for 0.5 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (230 mg, 95.0%) as a solid.

Provenance & Evidence