Hydrogen chloride-ethyl acetate → 9-(2-Methyl-3-furyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

HRID 886918Notes

Reaction equation

HRID 886918 reaction equation
[CH3:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7]1[C:17]2[O:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.C(OCC)(=O)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[CH3:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7]1[C:17]2[O:16][CH2:15][CH2:14][NH:13][CH2:12][C:11]=2[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578255tert-butyl 9-(2-methyl-3-furyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

Product 1

HCID 685785999-(2-Methyl-3-furyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochlorideYield 95%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(2-methyl-3-furyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (300 mg, 0.911 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (3 ml) was stirred at room temperature for 0.5 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (230 mg, 95.0%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-8b32d952177d418f9afff10d7c1180b0
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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