Hydrogen chloride-ethyl acetate → HCID 68578351, compound

HRID 886926Notes

Reaction equation

HRID 886926 reaction equation
[CH:1](/[C:4]1[C:14]2[O:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C:8]=2[CH:7]=[CH:6][CH:5]=1)=[CH:2]\[CH3:3].C(OCC)(=O)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH:1](/[C:4]1[C:14]2[O:13][CH2:12][CH2:11][NH:10][CH2:9][C:8]=2[CH:7]=[CH:6][CH:5]=1)=[CH:2]\[CH3:3]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68579627HCID 68579627, compound

Product 1

HCID 68578351HCID 68578351, compoundYield 87.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-[(1E)-propa-1-ene-1-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (178 mg, 0.615 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (121 mg, 87.7%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-a4d70a991ead4cd99baebd09e072ab27
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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