Hydrogen chloride-ethyl acetate → HCID 68578660, compound

HRID 886935Notes

Reaction equation

HRID 886935 reaction equation
[CH2:1]([C:3]1[C:13]2[O:12][CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)[CH3:2].C(OCC)(=O)C.[ClH:27]>C(OCC)(=O)C>[ClH:27].[CH2:1]([C:3]1[C:13]2[O:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68579772HCID 68579772, compound

Product 1

HCID 68578660HCID 68578660, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-ethyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (260 mg, 0.937 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (166 mg, 83.0%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-9f97e871dd32437dba4be2566fe77912
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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