Hydrogen chloride-ethyl acetate → HCID 68578465, compound

HRID 886938Notes

Reaction equation

HRID 886938 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[C:16]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1.C(OCC)(=O)C.[ClH:30]>C(OCC)(=O)C>[ClH:30].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[C:16]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578722HCID 68578722, compound

Product 1

HCID 68578465HCID 68578465, compoundYield 77.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(3-methoxypropyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (170 mg, 0.529 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (2 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of isopropyl alcohol and diisopropyl ether to give the desired product (106 mg, 77.9%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of isopropyl alcohol and diisopropyl ether

Sources & evidence

ORD record
ord-6e6421e945384fe1afaaaf1dd1bb6d8e
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

Loading…