Hydrogen chloride-ethyl acetate → HCID 68580318, compound

HRID 886943Notes

Reaction equation

HRID 886943 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]2[C:18]3[O:17][CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C:12]=3[CH:11]=[CH:10][CH:9]=2)=[C:5]([CH3:7])[N:6]=1.C(OCC)(=O)C.[ClH:32]>C(OCC)(=O)C>[ClH:32].[CH3:1][C:2]1[S:3][C:4]([C:8]2[C:18]3[O:17][CH2:16][CH2:15][NH:14][CH2:13][C:12]=3[CH:11]=[CH:10][CH:9]=2)=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578035tert-butyl 9-(2,4-dimethyl-1,3-thiazol-5-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

Product 1

HCID 68580318HCID 68580318, compoundYield 90.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(2,4-dimethyl-1,3-thiazol-5-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (240 mg, 0.666 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (180 mg, 90.9%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-ed7713ab1e604c22ae7bd949490553c2
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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