Hydrogen chloride-ethyl acetate → HCID 68578803, compound

HRID 886948Notes

Reaction equation

HRID 886948 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([C:6]2[C:16]3[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C:10]=3[CH:9]=[CH:8][CH:7]=2)[CH2:2]1.C(OCC)(=O)C.[ClH:30]>C(OCC)(=O)C>[ClH:30].[O:1]1[CH2:5][CH2:4][CH:3]([C:6]2[C:16]3[O:15][CH2:14][CH2:13][NH:12][CH2:11][C:10]=3[CH:9]=[CH:8][CH:7]=2)[CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68579372HCID 68579372, compound

Product 1

HCID 68578803HCID 68578803, compoundYield 92.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(tetrahydrofuran-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (430 mg, 1.35 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (320 mg, 92.8%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-84e74a959b65451e8e0ef3b698524645
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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