Hydrogen chloride-ethyl acetate → HCID 68578438, compound

Participants

Reaction Steps

A mixture of tert-butyl 9-(2,2,2-trifluoro-1-methylethyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (100 mg, 0.290 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (60.0 mg, 73.4%) as a solid.

Provenance & Evidence