Hydrogen chloride-ethyl acetate → HCID 68578438, compound

HRID 886956Notes

Reaction equation

HRID 886956 reaction equation
[F:1][C:2]([F:24])([F:23])[CH:3]([C:5]1[C:15]2[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)[CH3:4].C(OCC)(=O)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[F:24][C:2]([F:1])([F:23])[CH:3]([C:5]1[C:15]2[O:14][CH2:13][CH2:12][NH:11][CH2:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)[CH3:4]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578218HCID 68578218, compound

Product 1

HCID 68578438HCID 68578438, compoundYield 73.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-(2,2,2-trifluoro-1-methylethyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (100 mg, 0.290 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (60.0 mg, 73.4%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-2238216a0275483e88923225521f64f5
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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