Hydrogen chloride-ethyl acetate → 1055879-22-5

HRID 886957Notes

Reaction equation

HRID 886957 reaction equation
C(OC([N:8]1[CH2:14][C:13]2[CH:15]=[CH:16][CH:17]=[C:18]([C:19]([OH:21])=[O:20])[C:12]=2[O:11][CH2:10][CH2:9]1)=O)(C)(C)C.C(OCC)(=O)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[O:11]1[C:12]2[C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=2[CH2:14][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 685781121055880-94-8

Product 1

HCID 685781801055879-22-5Yield 83.6%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxylic acid (110 mg, 0.375 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (2 ml) were stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (72.0 mg, 83.6%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-1ef429158c354ad8ac7416bb5d53c134
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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