Hydrogen chloride-ethyl acetate → HCID 68578160, compound

HRID 886968Notes

Reaction equation

HRID 886968 reaction equation
[CH3:1][C@@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:25]=[CH:24][C:11]2[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][O:16][C:10]=2[CH:9]=1.C(OCC)(=O)C.[ClH:32]>C(OCC)(=O)C>[ClH:32].[ClH:32].[CH3:1][C@@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:25]=[CH:24][C:11]2[CH2:12][NH:13][CH2:14][CH2:15][O:16][C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578107HCID 68578107, compound

Product 1

HCID 68578160HCID 68578160, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 8-[(3R)-3-methylmorpholin-4-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (460 mg, 1.32 mmol), ethyl acetate (4 ml) and 4N hydrogen chloride-ethyl acetate solution (8 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (320 mg, 75.5%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-b2db4dcac0934f07aec2a1a767977b22
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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