Hydrogen chloride-ethyl acetate → HCID 68578684, compound

HRID 886974Notes

Reaction equation

HRID 886974 reaction equation
[CH:1]1([C:4]2[C:14]3[O:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C:8]=3[C:7]([F:22])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:29]>C(OCC)(=O)C>[ClH:29].[CH:1]1([C:4]2[C:14]3[O:13][CH2:12][CH2:11][NH:10][CH2:9][C:8]=3[C:7]([F:22])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68578388HCID 68578388, compound

Product 1

HCID 68578684HCID 68578684, compoundYield 67.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 9-cyclopropyl-6-fluoro-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (270 mg, 0.878 mmol), ethyl acetate (4 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (144 mg, 67.3%) as a solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and ether

Sources & evidence

ORD record
ord-cb966a31c77d4814810087dd4138ae4b
Source dataset
uspto-grants-2012_08
Patent number
US08247403B2

Reaction notes

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