1-Bromo-3-chloropropane → 5-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

HRID 887017Notes

Reaction equation

HRID 887017 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][N:11]([CH3:14])[C:10](=[O:15])[CH:9]=2)=[CH:4][CH:3]=1.Br[CH2:17][CH2:18][CH2:19][Cl:20]>>[Cl:20][CH2:19][CH2:18][CH2:17][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][N:11]([CH3:14])[C:10](=[O:15])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 569461995-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one

Product 1

HCID 569463035-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

Procedure

5-[4-(3-Chloro-propoxy)-phenyl]-2-methyl-2H-pyridazin-3-one was prepared from 5-(4-hydroxy-phenyl)-2-methyl-2H-pyridazin-3-one with 1-bromo-3-chloro-propane using the procedure described in Example 86 Step 3; Mp 90-91° C.; MS m/z 279 (M+H).

Sources & evidence

ORD record
ord-f2089ee29c9c49d6bda509b96fde9e15
Source dataset
uspto-grants-2012_08
Patent number
US08247414B2

Reaction notes

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