Hydrochloric Acid → 4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate hydrochloride

HRID 887067Notes

Reaction equation

HRID 887067 reaction equation
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[O:31][CH3:32])[CH2:21][CH2:20]3)=[O:13])=[CH:7][CH:8]=2)[NH:3]1.[ClH:33]>>[ClH:33].[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[O:31][CH3:32])[CH2:21][CH2:20]3)=[O:13])=[CH:7][CH:8]=2)[NH:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 574201774-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate

Product 1

HCID 574201814-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate hydrochloride

Procedure

4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate hydrochloride (24c) (Scheme 4) was prepared from 23c according to the protocol described for the compound 24a (Example 39). The hydrochloride salt 24c gave satisfactory 1H NMR spectral data. Off-white solid, 0.04 g (43%). MS (ESI): m/z=438.2 (M+H+).

Sources & evidence

ORD record
ord-e9b8cb5067624e4584fe6cf59f0f4fad
Source dataset
uspto-grants-2012_08
Patent number
US08247420B2

Reaction notes

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