Ammonia → Cyclopropyl(4-(trifluoromethyl)phenyl)methanamine

HRID 887242Notes

Reaction equation

HRID 887242 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=2)=O)[CH2:3][CH2:2]1.[NH3:16]>>[CH:1]1([CH:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=2)[NH2:16])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 11171894Cyclopropyl 4-trifluoromethylphenyl ketone

Product 1

HCID 22337655Cyclopropyl(4-(trifluoromethyl)phenyl)methanamine

Procedure

The title compound was prepared using the product from Example 141B and the procedures described in Examples 136A and 136B. 1H NMR (300 MHz, d6-DMSO) 7.92 (m, 4H), 3.24 (d, 1H), 1.92 (broad s, 2H), 0.93 (m, 1H), 0.50-0.27 (m, 4H); MS (DCI/NH3) m/e 216 (M+H)+.

Sources & evidence

ORD record
ord-17001ddf94954b7b855fc2e28e9e5933
Source dataset
uspto-grants-2012_08
Patent number
US08247413B2

Reaction notes

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