Acetic Anhydride → N-(Isoquinolin-3-yl)acetamide

HRID 887269Notes

Reaction equation

HRID 887269 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:12][C:13](OC(C)=O)=[O:14]>>[CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH:1][C:13](=[O:14])[CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 311869Isoquinolin-3-Amine

Product 1

HCID 12366594N-(Isoquinolin-3-yl)acetamide

Procedure

3-Aminoisoquinoline (495 mg, 3.44 mmol) was stirred in Ac2O (9 mL) at 60° for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo to provide the title compound which was used in the next step without further purification.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-fc92afb6bdd2453ab5fb523762a690c5
Source dataset
uspto-grants-2012_08
Patent number
US08247413B2

Reaction notes

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