Thionyl Chloride → 2-(4-Chlorophenyl)-2-methylpropanoyl chloride

HRID 887324Notes

Reaction equation

HRID 887324 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9](O)=[O:10])=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([Cl:16])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 804062-(4-Chlorophenyl)-2-methylpropionic acid

Product 1

HCID 135368632-(4-Chlorophenyl)-2-methylpropanoyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-(4-Chlorophenyl)-2-methylpropanoic acid (3.85 g, 19.4 mmol) in toluene (5 mL) and thionyl chloride (5.00 g, 3.1 mL) was heated at 80° C. for 2 hours. The mixture was cooled and concentrated under reduced pressure to provide the title compound.

Workup

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-86526bc526fa45dd831ddd12ca5f66e9
Source dataset
uspto-grants-2012_08
Patent number
US08247413B2

Reaction notes

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