反应详情

温度

180 °C

Copper (I) cyanide (14.1 g) and 2-bromo-5-trifluoromethylpyridine (3.00 g, 13.3 mmol) in dry DMSO (70 mL) were combined and heated at 180° C. for 2 hours, cooled, and poured into NH4OH (3M). The mixture was then extracted with ethyl acetate (3×500 mL), washed with water (1×200 mL), dried (MgSO4), filtered and the filtrate concentrated under reduced pressure to provide the title compound. 1H NMR (DMSO, 300 MHz) δ 8.22 (m, 1H), 8.42 (m, 1H), 9.01 (s, 1H).

1. temperaturecooled
2. extractionThe mixture was then extracted with ethyl acetate (3×500 mL)
3. washwashed with water (1×200 mL)
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationthe filtrate concentrated under reduced pressure