反应详情

2,3-dichloropyrazine (470 mg, 3155 μmol) was combined with 4-aminophenol (344 mg, 3155 μmol) and cesium carbonate (1233 mg, 3786 μmol) in DMSO (5 ml) and heated to 70 C. After 3 hours, the mixture was cooled to room temperature, transferred to a separatory funnel rinsing with ethyl acetate and water, the layers were separated and the aqueous was extracted with ethyl acetate (3×). The combined organics were rinsed with brine, dried over sodium sulfate, filtered and concentrated to yield a brown solid which was carried forward without purification.

1. temperatureheated to 70 C
2. customtransferred to a separatory funnel
3. washrinsing with ethyl acetate and water
4. customthe layers were separated
5. extractionthe aqueous was extracted with ethyl acetate (3×)
6. washThe combined organics were rinsed with brine
7. dry with materialdried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customto yield a brown solid which
11. customwas carried forward without purification