反应详情

2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene (2.5 g) was dissolved in CH2Cl2 and added to N-Boc-piperazine (2.5 g) and NaHCO3 (1 g) and stirred at RT overnight. The mixture was diluted with CH2Cl2 (100 ml), washed with sat'd NH4Cl, dried over MgSO41 filtered and concentrated. The residue was purified by silica gel chromatography (hexane, CH2Cl2:hexane 2:8) to give the compound as a yellow solid.

1. washwashed with sat'd NH4Cl
2. customdried over MgSO41
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified by silica gel chromatography (hexane, CH2Cl2:hexane 2:8)